As a big country with liver disease, liver tumor seriously threatens the life and health of our people. In fact, many celebrities have passed away due to liver cancer. In daily life, there are many patients who are found to have liver occupations in medical checkups, which also brings a lot of questions and confusions, why do I have it? How to treat it? Is there any salvation? Benign occupations such as hemangioma, hepatic cyst, liver abscess, and rare malignant occupations such as sarcoma will not be discussed here, but this article focuses on the related problems of hepatocellular carcinoma. Liver cancer can be categorized into two main types, primary liver cancer and metastatic liver cancer. I. Primary liver cancer Why do we get it? At this stage, primary liver cancer in China is still mostly secondary to chronic hepatitis B, cirrhosis, and chronic hepatitis C in Northeast China. In addition to viral hepatitis, fatty liver (non-alcoholic steatohepatitis), alcoholic liver disease, aflatoxin, and male hormone are all related to the onset of the disease. Men over 40 years of age with a history of chronic liver disease should be aware of regular medical checkups, and it is recommended that blood be drawn every 3 months for liver function, tumor markers (AFP and its isoformsCEACA199), and ultrasound (hepatobiliary, pancreatic, and splenic). What to do? Once the diagnosis is confirmed, the focus is on what to do next. One point should always be kept in mind: for liver cancer patients, the only hope for cure is surgical resection (hepatectomy or liver transplantation), and hepatectomy is preferred to liver transplantation. Liver transplantation has strict indications and selection criteria, and there is no advantage in recurrence and metastasis after transplantation compared with hepatectomy, and the economic cost is very large, so this article won’t expand on this topic. Preferred surgical resection, followed by the selection of hospitals and doctors, due to the late start of the domestic hepatobiliary surgery, but the rapid development of the level of uneven, it is recommended to have a strong technical reserves of specialized hospitals or large hepatobiliary surgical centers expert outpatient clinic. Unfortunately, only 10-20% of outpatient cases can be resected, and the majority of cases have no chance of surgery due to poor liver function or general condition, or the tumor has already metastasized inside and outside the liver. For these patients, we should not lose hope, as there are many patients who have regained surgical resection through traditional transhepatic artery catheterization chemotherapy (TACE) or combined with other local ablation treatments. Nowadays, pharmaceutical biotechnology is developing rapidly, and several new treatment methods have emerged, mainly targeted therapy and immunotherapy. Through traditional interventional treatment means, combined with targeted therapy and immunotherapy, it brings new hope to patients who originally had no possibility of cure. If it is still impossible to cure and resect the disease through hard work, the life of patients can be prolonged by the above means, giving them time to create social value. Second, metastatic liver cancer With the improvement of people’s living standard, the post-birth immunization of hepatitis B vaccine as well as the refinement of dietary structure and meat eating, the incidence rate of primary liver cancer gradually decreases, while the incidence rate of metastatic liver cancer rises year by year, which is more common with the source of gastrointestinal tract tumors. Like primary liver cancer, the only hope of cure for patients with metastatic liver cancer (simultaneous or heterogeneous metastasis) is radical resection, which is different from primary liver cancer in terms of the specific ways and methods of resection, and will not be discussed here. If one-stage resection is not possible, surgical resection can be obtained in the second stage after neoadjuvant chemotherapy combined with targeted therapy (with an effective rate of more than 50%). In conclusion, liver cancer patients should be treated with the goal of surgical resection, without giving up any hope of survival under the premise of safety. It is believed that with the continuous clinical transformation of basic research results of liver cancer and the emergence of new adjuvant drugs, liver cancer patients will be completely cured eventually.