whipple is also known as pancreaticoduodenectomy, postoperative bleeding can be minimized by strict fasting for one week, application of acid-suppressing drugs, inhibition of pancreatic enzyme secretion, gastroscopy and routine blood tests to detect occult bleeding in a timely manner, in accordance with medical advice. 1. Strict fasting for one week: fasting can promote anastomosis healing and reduce gastric and pancreatic fluid secretion to minimize bleeding caused by anastomosis rupture. 2. Application of acid-suppressing drugs: acid-suppressing drugs can reduce the secretion of gastric acid and prevent gastrointestinal bleeding caused by rupture of ulcers, representing drugs such as omeprazole and famotidine. 3. Inhibit pancreatic enzyme secretion: Inhibit pancreatic enzyme secretion can reduce the effect of pancreatic fluid on surgical wounds to avoid wound ulceration, representative drugs are octreotide, growth inhibitor. 4. Gastroscopy and blood test: Regular postoperative gastroscopy and blood test can detect hidden bleeding and take timely treatment to reduce postoperative bleeding. It is recommended that patients after Whipple’s operation should be hospitalized for systematic treatment as prescribed by the doctor, and after discharge from the hospital, they should also have a light diet to avoid excessive secretion of gastric and pancreatic juices that may affect wound healing and cause bleeding, and consult a medical professional in case of any discomforts. In addition, the specific use of the above drugs should be under the guidance of a doctor.