Hyaluronidase is mainly used after surgery or trauma to promote the reduction of local wound edema, but also to accelerate the onset of local anesthetic drugs, to reduce the pain of local anesthetic drug injection symptoms, but also can be used in medical aesthetics. Hyaluronidase, also known as hyaluronic acid, is essentially a mucopolysaccharide with relatively low content in the human body, mainly found between the epidermis and the dermis, and promotes cell adhesion through protein binding. Hyaluronidase is a good moisturizer for aging skin, and can also be used as a sunscreen tool to reduce the damage caused by sunlight. Hyaluronidase can relieve skin aging, improve skin nutrient metabolism, promote wound healing, and improve facial wrinkles, with relatively few side effects and a good safety profile, making it more suitable for clinical use. Patients are advised that if they need to use it, they should go to a regular hospital or a regular beauty institute to use it under the guidance of a physician.