Atorvastatin can be replaced with simvastatin, fenofibrate, ezetimibe, niacin, etc., as prescribed by the doctor. Atorvastatin is mainly used to treat hypercholesterolemia blood or mixed hyperlipidemia, to lower cholesterol, and at the same time can reduce the risk of coronary heart disease, such as the use of atorvastatin calcium tablets is not effective or adverse reactions, can be replaced with the same type of statin drugs, such as simvastatin, resuvastatin, pravastatin and so on. It can also be replaced with a beta-lipid-lowering drug, such as fenofibrate, which mainly lowers triglycerides, but also lowers cholesterol, and can be associated with adverse effects such as gastrointestinal reactions and muscle weakness. In addition, ezetimibe is to inhibit the absorption of cholesterol in the small intestine and lower cholesterol levels, and common adverse reactions include gastrointestinal reactions such as abdominal pain and diarrhea. Finally, niacin can treat hyperlipidemia, but it needs to be used with caution in patients with arterial bleeding, diabetes mellitus, glaucoma, gout, hyperuricemia, liver disease, ulcer disease, and hypotension, etc. Adverse reactions include gastrointestinal reactions, skin redness, etc. High doses of niacin can lead to hyperglycemia, hyperuricemia, arrhythmia, and hepatotoxic reactions. Atorvastatin can be replaced with a variety of drugs, but need to pay attention to the indications and contraindications, it is recommended that under the guidance of a professional doctor, a reasonable choice.