Itchy bumps on the face may be caused by atopic dermatitis, acne, papular urticaria and other factors, mainly the use of topical as well as oral medications to treat different triggers, the use of different medications, such as tacrolimus ointment, fusidic acid cream and so on. 1. Allergic dermatitis: for example, allergic reaction to some food, will make the face itchy, after diagnosis, can be used topical tacrolimus ointment, glycerite lotion treatment, and with oral levocetirizine hydrochloride oral solution and other drugs. 2. Acne: usually caused by Propionibacterium acnes infection, after diagnosis, can be treated with topical clindamycin gel, fusidic acid cream and other drugs, but also with oral roxithromycin capsules, tetracycline tablets and other drugs. 3. Papular urticaria: It may be related to mosquito bites, which cause small bumps on the facial skin with itching. After diagnosis, it can be treated with topical mupirocin ointment, fusidic acid cream and other medications. When the symptoms are more serious, antihistamines such as loratadine and cetirizine can be used, which have anti-allergic and antipruritic effects and can shorten the duration of the disease. When using medication, it is important to follow the doctor’s guidance, safe and reasonable use of drugs, do not use drugs indiscriminately.