There are many causes of blistering (blistering) on the face, including herpes simplex and impetigo, which can be intervened with the use of medication. Any treatment needs to be tailored to the condition, so there is no absolute quickest cure. 1. Herpes simplex: Herpes simplex is a skin disease caused by human herpes virus infection, and small blisters may appear on the face. It can be treated with oral antiviral therapy with acyclovir. When the blisters are unbroken, intervention can be made through the use of medications such as glycerite lotion and acyclovir ointment. When the blisters rupture secondary to bacterial infection, antibiotic ointment such as mupirocin ointment can be used externally. 2. Impetigo: a skin disease caused by Staphylococcus aureus or Streptococcus b hemolyticus. Simple isolation should be carried out, can be localized mupirocin ointment and other drugs for local anti-infection treatment. Those with generalized lesions and severe systemic symptoms should take oral antibiotics, such as penicillin, in a timely manner. The appearance of facial blisters and other symptoms, it is recommended to promptly go to the hospital; the above drugs need to be used under the guidance of clinicians.