Patients with swollen hands during intravenous infusion with mannitol should stop the infusion at first. Mannitol is a relatively stimulating drug that may stimulate the local venous vessels, leading to local sterile inflammation and causing swelling of the hands. Patients who encounter this situation can use local hot compresses to promote the local blood circulation of the patient as much as possible to accelerate the decreasing of local inflammatory swelling and achieve the effect of swelling reduction. Local physical therapy, such as microwave therapy, infrared therapy, short-wave therapy, etc., can promote local blood circulation, accelerate tissue repair, and have the effect of reducing swelling. If the swelling is accompanied by pain, you can take non-steroidal anti-inflammatory drugs, which can relieve pain and eliminate local sterile inflammation at the same time. This hand swelling is mostly caused by the absorption of the surrounding tissue fluid by mannitol in the tissue. Usually, the patient can be given a local massage to accelerate the discharge of the fluid, or a hot towel can be applied locally to increase the local circulation and speed up the absorption.