Retrograde ejaculation is a condition in which semen is not discharged from the urethra after reaching orgasm, but is discharged retrograde into the bladder. Retrograde ejaculation can be treated by taking adrenomimetic drugs and anticholinergic drugs, but whether they are effective varies from person to person. 1. Phenylephrine drugs: Phenylephrine drugs can be used to treat retrograde ejaculation with an intact bladder neck. These drugs can act on the alpha receptor of the bladder neck, thus increasing the contraction ability of the smooth muscle of the bladder neck and blocking the retrograde entry of semen into the bladder. Commonly used drugs include: ephedrine, promethazine, norepinephrine and so on. 2. Anticholinergic drugs: Anticholinergic drugs can effectively block the action of acetylcholine on the bladder neck, thus making the bladder neck tension increase, thus playing a role in the treatment of retrograde ejaculation. Commonly used drugs are: brompheniramine, phenylpropanolamine and so on. Patients with retrograde ejaculation are advised to seek medical attention, identify the cause of the disease and then treat it under the guidance of a doctor. It should be clear that the effectiveness of drug treatment for this disease is uncertain, so the treatment given by the doctor is not necessarily medication, and it is sufficient to follow the doctor’s instructions.