In the human anatomy, the stomach is on the left side of the body and the liver is on the right side of the body, but both overlap to a small extent in the subxiphoid region. The nerve distribution of the organs in the abdominal cavity is relatively vague, so it is difficult to localize the pain in the internal organs. Therefore, pain in the middle of the upper abdomen should be examined to determine whether the pain is caused by stomach, liver or heart disease. Gastroscopy is the first choice to check stomach disease, and ultrasound is the first choice for liver disease, because gastroscopy is not easy to accept because of poor compliance, so we can first perform ultrasound and liver function tests when pain occurs in the middle of the upper abdomen, if there is no abnormality in ultrasound and liver function tests is generally the possibility of stomach disease, then you should go for gastroscopy, and after confirming the diagnosis, then choose the appropriate plan to carry out according to the test results After confirming the diagnosis, you can choose the appropriate plan to treat you according to the test results. In addition, for older patients with upper abdominal pain, do not forget to have an electrocardiogram to exclude cardiac changes. In conclusion, it is necessary to actively seek medical attention for pain in the middle of the rib cage and to undergo abdominal ultrasound, electrocardiogram and electronic gastroscopy under the guidance of a physician to assist in the diagnosis.