Late stage hepatocellular carcinoma presents with coma, and the survival time varies from 1-2 weeks. Because this period has developed serious internal environmental disorders, complicated by increased blood ammonia, is due to the development of hepatic encephalopathy. In addition, the consumption that appears in the late stage of tumor is manifested as anemia, hypoproteinemia, ion disorder, cachexia depletion state, and the patient will also have distant organ metastasis, and if brain metastasis appears, the patient will be in continuous coma, and the patient with brain edema will have brain herniation, so the patient’s life will be in danger at any time. In contrast, if liver cancer is diagnosed early and treated timely, the survival period is relatively satisfactory. For patients with advanced stage, they can also choose adjuvant treatments to control the development of tumor, most commonly interventional embolization therapy or systemic intravenous chemotherapy, which can prolong the patient’s life and achieve the purpose of improving the quality of life in the late stage.