Lymphoma does not necessarily cause generalized wandering tingling. Lymphoma’s lesions affect a wide range of areas, and patients are often accompanied by fever, emaciation, night sweats, and so on, which will cause malignant disease in the end. Lymphoma can cause pain by pressing the nerves, and other symptoms include dyspnea, nasal congestion, nosebleed, enlarged lymph nodes, localized mass, etc., which may not necessarily manifest as generalized wandering pain. The common causes of generalized wandering pain may be rheumatism, rheumatoid, osteoporosis, neurosis, etc. Other factors include overexertion, cold, lack of sleep, depression, etc., and this kind of pain is a manifestation of neuralgia. Patients with lymphoma or generalized wandering tingling should actively seek medical attention, improve the examination, clarify the cause and diagnosis, and standardize the treatment under the guidance of physicians.