Ankylosing spondylitis shoulder pain can be treated with medication, physical therapy or surgery. 1. Medication: Some patients with ankylosing spondylitis who have obvious shoulder pain symptoms can be treated with non-steroidal anti-inflammatory drugs under the guidance of a doctor, such as meloxicam and celecoxib, which can rapidly improve the pain. 2. Physical therapy: Physical therapy, such as acupuncture, hot compresses, massage, and functional exercises can also be chosen. 3. Surgery: If the shoulder damage is more serious and there are serious structural abnormalities in the joints, surgical treatment, such as arthroplasty, may be needed. If the symptoms of ankylosing spondylitis shoulder pain are not relieved, or accompanied by other symptoms, you should go to the hospital in time, and give targeted treatment after clarifying the cause.