Chronic lymphocytic leukemia can be treated with traditional Chinese medicine, which can be used according to the different types of evidence. Chronic lymphocytic leukemia can be treated with a combination of Chinese and Western medicines according to the condition. In the early stage, Chinese medicine can be used to support the positive and supplemented by softening and dispersing (softening and dispersing the hard lumps); in the middle and late stage, chemotherapy can be used to get rid of the evil spirits, and traditional Chinese medicines can support the positive and cultivate the root. Chinese medicine classifies chronic lymphocytic leukemia into two types: phlegm-stasis-obstruction syndrome and qi and yin deficiency (deficiency of both qi and yin) syndrome. Symptoms of phlegm and blood stasis obstruction syndrome include phlegm nuclei (subcutaneous lumps swollen up like nuclei) in the armpits, neck and groin, single or bunches, dark complexion, low fever, malaise, fixed, solid or movable abdominal masses, pain or no pain, skin petechiae or epistaxis (nosebleed), etc. The treatment is to soften and disperse the lumps and dispel the blood stasis and resolve the phlegm, and the treatment can be Taohong Sizuo Tang combined with Chaihu Shu Hepatophoresisan with additions and subtractions. Symptoms of qi and yin deficiency include fatigue, low-grade fever, lack of color, shortness of breath and laziness, heat in the hands, feet and heart, lumbar and knee soreness and tenderness (feeling of soreness and weakness in the lumbar and knee regions), skin petechiae, ecchymosis, loss of appetite, etc. The treatment is to nourish yin and benefit qi, and can be added and reduced by Sijunzi Tang with Sashen Maidong Tang. The adverse reactions and contraindications of the above drugs are not clear. If you feel unwell, it is recommended to go to the hospital and cooperate with the doctor for active treatment.