Does Uric Acid Rebound When Febuxostat Is Stopped?

Suddenly stopping taking Febuxostat can cause a rebound increase in uric acid and may even trigger a gouty attack. It is generally not recommended that patients treated with Febuxostat stop taking the drug easily. Febuxostat is a xanthine oxidase inhibitor that reduces uric acid levels in gout patients by inhibiting the production of uric acid, and it is not generally recommended for the treatment of patients with asymptomatic hyperuricemia. Gout patients who are already taking febuxostat may experience a rebound increase in uric acid if they suddenly stop taking the drug, which may even trigger a gouty attack. Therefore, it is generally not recommended to stop taking Febuxostat after the patient’s uric acid level has reached the standard. Instead, it is recommended to maintain the treatment at the minimum dose, and patients who need to stop taking Febuxostat due to changes in medical conditions, personal constitution and other factors should stop taking it gradually under the guidance of a physician. Febuxostat should be used under the guidance of a physician, and it is recommended that patients go to the Department of Rheumatology and Immunology of a regular hospital for relevant consultation.