Liver fibrosis 10.9kPa is difficult to be reversed, and the treatment mainly includes cause-specific treatment, antifibrotic treatment, hepatoprotective and anti-inflammatory treatment. 1. Cause-specific treatment: When severe liver fibrosis occurs, the first step is to treat the specific cause of the disease. If it is caused by hepatitis B, antiviral treatment, such as entecavir and sofosbuvir, etc.; if it is autoimmune hepatitis, glucocorticosteroid treatment can be used; if it is alcoholic hepatitis, alcohol should be stopped immediately. 2. Anti-fibrotic treatment: For the formed liver fibrotic tissues, anti-fibrotic drugs can be used to promote the fibrotic degradation, such as colchicine, magnesium isoglycyrrhizinate and so on. 3. Hepatoprotective and anti-inflammatory treatment: most of the liver fibrosis is derived from hepatitis, hepatoprotective and anti-inflammatory drugs can be used to reduce the hepatitis activity, so as to avoid the production of new fibrotic tissues, such as compound glycyrrhizin preparation, reduced glutathione and so on. When serious liver fibrosis occurs, the specific cause should be clarified and standardized treatment should be carried out under the guidance of doctors.