The causes of sweating in the middle of the night all over the body are generally physiological factors and pathological factors (such as tuberculosis, hyperthyroidism, etc.). 1. Physiological factors: generally due to the high temperature of the room, sleeping with too much clothing, thick quilt, etc. In these cases, the body needs to increase heat dissipation through sweating to reduce body temperature, so there will be sweating in the middle of the night all over the body wet. 2. Tuberculosis: when the human body is infected with Mycobacterium tuberculosis, the metabolites secreted will stimulate the human nervous system, resulting in sweat gland secretion dysfunction, leading to sweating in the middle of the night all over the body wet. 3. Hyperthyroidism: hyperthyroidism patients due to increased secretion of thyroid hormones can lead to an increase in the body’s metabolic rate, which can increase the body’s heat production, resulting in sweating in the middle of the night all wet. It is recommended that the middle of the night sweating all over the body wet may also be caused by other reasons, should be timely medical examination, according to the specific circumstances, under the guidance of the doctor, symptomatic treatment.