Chronic disease face manifests as a dull and unlit face, may have pigmentation, emaciated face, eyes are listless, hollow, indifferent or worried expression, mostly seen in chronic wasting diseases, as follows: 1, long-term anemia, the patient can show a pale, yellowish face, tired expression. 2, patients with liver cirrhosis, liver cancer show a thin face, dull skin, some patients can appear obvious yellow staining, both cheeks can have brown Patients with uremia show facial edema and pale or dark face. 4. Patients with hypothyroidism show pale face, edema, dull gaze, slow reaction, and thinning hair and eyebrows. 5. Patients with systemic lupus erythematosus show pale face and erythema with butterfly-like distribution on the nose, bilateral cheekbones and cheeks.