Patients who take more isoniazid orally in large quantities will trigger poisoning. Patients should go to the hospital as soon as possible and give treatment such as emetic, gastric lavage and diuretic, as well as reasonable rehydration and diuresis to promote the excretion of isoniazid drug. In addition, patients with severe isoniazid poisoning should also clear the isoniazid in the blood through blood purification, such as hemodialysis or peritoneal dialysis, which can achieve the purpose of rapid removal of isoniazid and thus avoid the therapeutic effect of organ insufficiency. Isoniazid, also known as Remifentan, is one of the most common first-line anti-tuberculosis drugs and is often used in combination with other anti-tuberculosis drugs to treat various tuberculosis diseases in clinical practice. Isoniazid is a very effective anti-tuberculosis drug, but also has more adverse effects and side effects, such as isoniazid may cause gastrointestinal adverse reactions, central or peripheral nerve damage, blood system damage, etc. Also, long-term use of isoniazid may lead to secondary vitamin B deficiency.