Discomfort in the stomach after meals may be due to physiological reasons, such as overeating, and regulating eating habits can improve the symptoms. It can also be caused by pathological reasons, such as chronic gastritis, gastric ulcer, duodenal ulcer, etc. Treatment includes medication and surgery. 1. Physiological causes: If the patient overeats, eats too much at one time or eats too fast, the food may not be fully digested, causing symptoms of stomach discomfort. The symptoms can be improved after adjusting the dietary habits. 2. Pathological causes (1) Chronic gastritis: Chronic gastritis may be caused by Helicobacter pylori infection, autoimmunity and other factors. Patients can follow the doctor’s instructions to use medication, such as rabeprazole, magnesium aluminum carbonate and so on. For high-grade intraepithelial neoplasia, surgery can be considered for treatment. (2) Gastric ulcer: gastric ulcer refers to the gastric mucosa in the gastric acid, pepsin invasion, defense imbalance, digestion of their own mucosa, the formation of local inflammatory defects in the disease. Patients can follow the doctor’s instructions to use medication, such as eplazole, famotidine and so on. (3) duodenal ulcer: duodenal ulcer patients can follow the doctor’s instructions to use medication, such as lansoprazole, amoxicillin and so on. If the effect of medication is not satisfactory or the condition worsens, surgical treatment can be considered. Stomach discomfort after meals, there may be other reasons, the patient should follow the doctor’s instructions for treatment, do not blindly treat yourself, so as not to delay the condition.