The hazards of playing wrinkle injections include allergic reaction, infection and skin necrosis, etc. The details are as follows: 1. Allergic reaction: such as congenital allergy, their own congenital immune system defects, stimulation by external factors leading to skin allergies. Playing wrinkle injection makes our local skin damaged, stimulated by allergens lead to the body’s immune response activity abnormal formation of allergic reactions, severe cases accompanied by headache and other adverse reactions. 2. Infection: the injection site does not pay attention to hygiene and cleanliness, may lead to infection. 3. Skin necrosis: improper injection of wrinkle reduction needle will form nodules, enter the blood vessels will lead to vascular embolism, serious skin necrosis. In addition, improper injection of wrinkle removing needle may also lead to the phenomenon of asymmetry and incoordination of facial expression; so in order to achieve a relatively good prognosis, it is recommended to go to the hospital in a timely manner to carry out standardized treatment under the guidance of a professional physician, to avoid delaying the condition and causing adverse consequences.