Nervousness and fear when flying is mainly common in clinical phobias, for this condition, in clinical treatment is generally based on psychotherapy and medication. Psychotherapy can be used cognitive behavioral therapy, including the patient can go to cognitive safety of airplane travel, in addition, through the imagination of exposure, so that patients can be systematically desensitized, and eventually can actually walk on the plane, to be able to fly, need a gradual desensitization process. Medication is also clinically important as a treatment tool, such as the application of anti-anxiety drugs or antidepressants, with benzodiazepine anti-anxiety drugs alprazolam, lorazepam, eszopiclone as the main drugs, which can be applied in small doses for a short period of time. Antidepressant drugs can choose sertraline, fluoxetine, escitalopram and other drugs, through the whole course of systemic treatment, can achieve good therapeutic results.