If the root canal calcification of apical inflammation cannot be anesthetized, the root canal can be unblocked first, and nerve block anesthesia or apical surgery can be considered if necessary. If you can’t get anesthesia for root canal calcification, it means that the root canal is calcified and causing obstruction, so you should have a professional doctor remove the calcified tissues through microscope, and perform root canal unblocking for apical inflammation. If it is not possible to unblock the root canal, we have to consider doing apical surgery to unblock the root canal in order to complete the next step of the treatment. For the case of apical inflammation root canal calcification, it is recommended that a professional dentist conducts an examination to analyze and determine whether the nerve is necrotic or not. General anesthesia can also be performed with block anesthesia, which is not affected by root canal calcification. If the nerve is necrotic and no pain can be felt, anesthesia can be done without anesthesia. If the patient’s tooth nerve is sensitive, it is necessary to take into account the actual situation and adjust the root canal calcification treatment program.