Normal human spleen is about 3~4cm thick, spleen 4.3cm belongs to splenomegaly, which may be caused by primary diseases, such as cirrhosis, lymphoma, systemic lupus erythematosus, schistosomiasis, malaria and so on. Splenomegaly 4.3cm may cause harm such as anemia, bleeding and thus life-threatening. Primary diseases may cause thickening of the spleen, hypersplenism manifestation, leading to anemia with reduced blood cells, easy to cause infections, and even easy to cause bleeding tendency. These diseases are very dangerous and may affect life. The texture of the spleen is relatively brittle, and an enlarged spleen is prone to rupture caused by external forces, resulting in hemorrhage and life-threatening injuries. Splenic thickness of 4.3cm is recommended to consult a doctor in time to find out the cause of the disease and treat it as soon as possible, so as to avoid delaying the condition.