The main reason is that although Eusebio is a combination of estrogen and progestin, the progestin in Eusebio uses drospirenone, which can counteract estrogen. Short-acting contraceptives can cause weight gain mainly because they contain estrogen, which can cause water and sodium retention in women and therefore lead to weight gain. The drospirenone in Eusebio counteracts estrogen, reducing the possibility of obesity, and most of the time, obesity does not occur when taking Eusebio. In addition, if you take Eusebio for contraception or treatment, be sure to know the indications. If you have uterine fibroids, you should not use Eusebio for contraception or treatment.