Patients with mediastinal small cell neuroendocrine carcinoma pain can use Tramadol Hydrochloride Injection for pain relief. If mediastinal neuroendocrine cancer patients have pain, they should seek medical treatment in time and follow the principle of three-step treatment of cancer pain under the guidance of physicians to reduce pain and improve the quality of life. First-step painkillers: mainly non-steroidal anti-inflammatory drugs, such as diclofenac sodium extended-release tablets, indomethacin, etc., which are mainly applicable to patients with mild pain; Second-order painkillers: mainly weak opioids, such as codeine tablets, tramadol hydrochloride injection, etc., mainly applicable to toxic pain; Third-step painkillers: generally strong opioids, such as morphine sulfate extended-release tablets, hydroxycortisone hydrochloride extended-release tablets, fentanyl transdermal patches and so on, which are suitable for patients with severe pain. Tumor patients with pain, we should consult the doctor in time, do not use drugs privately, but under the guidance of physicians, standardized drug therapy.