Rectal cancer with liver, kidney and lung metastasis can be treated with chemotherapy, through which the survival period of patients can be prolonged. Rectal cancer with liver and lung metastasis usually belongs to the advanced stage of rectal cancer, at this time, surgical resection is not possible, and chemotherapy is usually the main treatment, such as adopting chemotherapeutic drugs of 5-fluorouracil, irinotecan, capecitabine, oxaliplatin and so on, which can prolong the survival period of patients with rectal cancer, and improve the quality of life of patients. The main treatments for rectal cancer include surgical resection, radiotherapy and chemotherapy. Chemotherapy refers to the use of tumor cells’ high sensitivity to chemicals to selectively kill tumors. Chemotherapy for colorectal cancer usually takes fluorouracil as the basic drug, and the routes of chemotherapy include postoperative peritoneal thermal perfusion chemotherapy and systemic intravenous drug administration. Diagnosed with liver, kidney and lung metastasis of rectal cancer, one should promptly and actively cooperate with doctor’s treatment plan in order to improve the survival period.