The principles of treatment for mandrake poisoning, first aid is based on gastric lavage, diarrhea and the administration of antagonists for treatment. Mandala poisoning may appear palpitations, chest tightness and other symptoms, suspected mandala poisoning need to call the emergency number, sent to the emergency room for treatment. The diagnosis of mandrake poisoning requires medication, which may include the use of antagonists, such as subcutaneous injections of 3% nitroprusside solution to antagonize the effects of scopolamine, once every 15 minutes until the pupils are reduced in size, the light reflex is present, and the mucous membranes of the oral cavity are moistened. Oral poisoning can be given gastric lavage, diarrhea, gastric lavage with 1:5000 potassium permanganate or 1% ellagic acid, diarrhea with magnesium sulfate or enema. If the poisoning time is long, saline can be used to do high intestinal lavage, so as to rapidly remove the poison, and patients with mandrake poisoning can also be given rehydration, protection of the gastric mucosa, fasting and other symptomatic supportive treatment.