Lymph node tuberculosis is not always applied in the way of quadruple medication, but sometimes two or three drugs are applied for control, which is related to one’s own disease condition and drug tolerance. Lymph node tuberculosis is a kind of extrapulmonary tuberculosis, which requires regular application of anti-tuberculosis drugs for management, and the main principles of drug administration are early, regular, sufficient amount, combination and long-term medication. Commonly used drugs are isoniazid, rifampicin, streptomycin, pyrazinamide, etc. The specific drug program is not necessarily a quadruple drug, but also choose two or three of them to apply control. During the period of anti-tuberculosis drug treatment, it is necessary to pay attention to closely monitor the changes of liver and kidney functions and other body indexes, and after finding abnormalities, it is necessary to promptly enter the hospital to seek medical treatment and active diagnosis and treatment. The above drugs need to be standardized treatment under the guidance of clinicians to avoid delays.