After Parkinson’s is diagnosed, it can be treated by symptomatic drugs and causative drugs according to the patient’s specific condition and symptoms, such as commonly used antipsychotics, anticholinergic drugs, anti-Parkinson’s drugs, etc.
1. Causative drug treatment: the choice of treatment drugs varies according to symptoms and age.
(1) Patients <65 years old without mental retardation can choose: (1) non-ergot DR agonists, such as piribedil extended-release tablets; (2) MA0-B inhibitors, such as selegiline; (3) anticholinergic drugs, such as phenazopyridine, if the tremor is obvious; (4) COMT inhibitors, such as entacapone; (5) compound levodopa: when the above effects are not good, it can be used in addition.
(2) Patients ≥65 years of age or with mental retardation: prefer compound levodopa, and if necessary, add DR agonists such as bromocriptine, MAO B inhibitors such as selegiline, or COMT inhibitors such as entacapone. Benzhexol should not be used in elderly men as much as possible, unless there is severe tremor that interferes with the patient's daily life.
2. Symptomatic drug therapy:
(1) Psychiatric disorders: levodopa controlled release can be applied for sleep disorders, or sedative-hypnotics such as eszopiclone can be added. Non-classical antipsychotic drugs can be used, such as the commonly used clozapine and other drugs; cholinesterase inhibitors, such as donepezil, can be used in the presence of cognitive impairment;
(2) Autonomic dysfunction: constipation can be relieved by diarrhea-inducing drugs, such as lactulose, etc., and can also be appropriately combined with medication to promote gastrointestinal peristalsis, such as mosapride; urinary disorders can be treated with peripheral anticholinergic drugs, such as oxybutynin.
The use of specific drugs, need to be under the guidance of a professional doctor.