Donors may experience some discomfort during bone marrow transplantation, but after long-term clinical research, it is not harmful to donors. 1. Before bone marrow transplantation, donors need to take mobilizing injection, after injection, they may experience nausea, headache, fever, anorexia, insomnia and other discomforts, due to the different physical qualities of each person, the degree of discomforts are not the same, but basically they are all within the tolerable range. With the discontinuation of the mobilization injection, the discomfort will disappear after the donor rests for a period of time. 2. There are hematopoietic stem cells in our bone marrow, although the number is not very large, but it can replicate the exact same cells as itself. When donating bone marrow, a small portion of the bone marrow will be extracted from the body, and some of the hematopoietic stem cells will be lost, but the rest of the hematopoietic stem cells will be replicated quickly, so that the hematopoietic function can be restored to normal in a short period of time. Therefore, bone marrow donation does not cause any substantial harm to the donor. After bone marrow donation, you should follow the doctor’s instructions to take medication on time, go to the hospital for regular checkups, and consult the doctor in time if any discomfort occurs during the period.