Positive H. pylori is recommended to be treated with triple or quadruple drugs. It has been found that H. pylori is an independent risk factor for the development of chronic gastritis, gastric ulcer, gastric cancer and other diseases, so medication is needed to inhibit H. pylori. The specific program to eradicate H. pylori is to choose triple therapy or quadruple therapy, triple is proton pump inhibitor such as omeprazole + 2 antibiotics such as clarithromycin, metronidazole and so on. Currently, quadruple therapy is more recommended as the first-line treatment option. Quadruple therapy is proton pump inhibitor such as omeprazole + bismuth agent such as bismuth potassium citrate + two kinds of antibacterial such as clarithromycin, amoxicillin and so on. However, the choice of specific antibiotics should be based on local drug resistance. The presence of positive Helicobacter pylori also requires timely consultation and medication under the guidance of a doctor.