What are anticoagulants?

In modern society, there is great material abundance and people have moved from subsistence to well-off, and now they can choose their favorite food as they wish. However, due to the influence of many factors such as improper diet and environmental degradation, the frequency of cardiovascular and cerebrovascular diseases has caused us to have frequent contact with anticoagulants. Anticoagulants are drugs that can be used to prevent and control intravascular embolism or thrombosis, as well as to prevent stroke or other thrombotic diseases. They are drugs that prevent the clotting process by affecting certain clotting factors in the clotting process. In normal people, because of the complete blood coagulation system and anticoagulation and fibrinolysis system, blood neither coagulates nor bleeds in the blood vessels, and always flows freely to complete its function, but when the body is in a hypercoagulable state or the anticoagulation and fibrinolysis are weakened, thromboembolic disease occurs. At this time is the need to use anticoagulants, otherwise its consequences are to cause stroke and other thrombotic diseases. The most frequently used anticoagulants in hospital clinics include: non-intestinal anticoagulants (such as heparin), coumarin anticoagulants (such as warfarin), anti-platelet agglutination drugs (such as aspirin), etc. The specific classification of anticoagulant drugs is mainly as follows: a. Coumarin anticoagulants, more commonly used are double coumarin, warfarin and new anticoagulation, these drugs by antagonizing vitamin K to make These drugs anticoagulate by antagonizing vitamin K to reduce the synthesis of prothrombin and factor VII, IX and X in the liver. These drugs are characterized by slow onset of action, but longer duration of action, and are suitable for those who need prolonged anticoagulation, such as deep vein thrombosis and pulmonary embolism. Second, antiplatelet drugs, such as aspirin and pentoxifylline, are effective in preventing thrombosis. Because aspirin has an inhibitory effect on platelet cyclooxygenase and can prevent platelet cyclooxygenase from converting arachidonic acid into prostaglandin intermediates. Third, heparin anticoagulants, both in vivo and ex vivo have a strong anticoagulant effect, which is achieved through antithrombin III, which has an inhibitory effect on multiple links of the coagulation process, and its effect is rapid. Fourth, snake venom thrombolytic agents such as defibrinase, antithrombin and thrombin can dissolve the formed thrombus to make the blood vessels reopen. Fifth, new oral anticoagulants, at present, new oral anticoagulants refer to the newly developed and marketed oral factor Xa and IIa direct inhibitors, the former including apixaban, rivaroxaban, edoxaban, etc., and the latter with dabigatran. Although there are more anticoagulant drugs currently used in clinical practice, the specific use of them needs to be determined according to the individual’s physical condition and medical advice.