Whether creatinine 160umol/L is serious or not depends on the cause of the elevated creatinine and cannot be generalized. Elevated creatinine can be categorized into physiological and pathological causes. Physiological causes such as strenuous exercise, excessive consumption of meat and so on can lead to creatinine increase, usually after the elimination of the triggering factors, creatinine can gradually return to normal, generally not serious. Pathologic causes such as acute causes of renal insufficiency, usually refers to a variety of causes of transient renal impairment, after active treatment, creatinine usually can restore symptoms, usually not serious. Chronic renal insufficiency such as various types of glomerulonephritis, diabetic nephropathy, hypertensive nephropathy and other causes of renal injury, creatinine elevation, usually can not be cured, most of the chronic causes can not be cured, usually more serious. It is recommended that patients with creatinine 160μmol/L should go to the nephrology department of regular hospitals in time to improve the relevant examinations under the guidance of specialists, and if it is caused by pathological factors, it is recommended to standardize the treatment to avoid the development of the disease.