Acanthosis nigricans is a symmetrical skin roughness, thickening, darkening, and darkening lesion, which is often complicated by endocrinopathy, malignant tumor, and diabetes. The formation of acanthosis nigricans is mainly related to environmental changes in the patient’s body and skin viral infections. The association between acanthosis nigricans and obesity is small and belongs to two diseases. Acanthosis nigricans can be cured by dermatological treatments, such as appropriate laser irradiation, to reduce or eliminate it. In addition to this, the treatment of fire acupuncture in acupuncture can be used to reduce it and gradually achieve its elimination.