Warning against the dangers of excessive chemotherapy: a rational analysis of benefits and risks

Chemotherapy is one of the main means of cancer treatment, which has been well known to the majority of patients. However, there are great limitations and drawbacks in current cancer chemotherapy: once it is used improperly or excessively, its effect is counterproductive, which not only reduces patients’ quality of life, but even jeopardizes their lives. Relevant factors to consider are as follows: 1. For advanced cancers (already metastasized or relapsed and metastasized after surgery), chemotherapy is only effective for 25-35% of them, that is to say, chemotherapy is ineffective for about 70% of the advanced cancers. For colon cancer, kidney cancer, liver cancer, melanoma and other cancers, the effective rate is even lower. Therefore, before chemotherapy, patients should consider whether they are willing to bear 100% of the toxicity of chemotherapy to obtain a short-term efficacy of 30%. 2. For advanced cancers, chemotherapy is generally incurable. What is the significance of the so-called 30% efficacy? It means that if 100 patients are treated with chemotherapy, about 70 of them will be ineffective and the tumor will not be controlled. About 30 patients will have some control of their tumor growth after 2 to 3 cycles of chemotherapy. Unfortunately, this control is not indefinite, but very short-lived, usually 2 to 6 months, and the residual tumor will quickly become resistant to the drug and re-accelerate its growth. And once the tumor is resistant to chemotherapy, the effectiveness of switching chemotherapy regimens again drops to less than 10%, and greater chemotherapy toxicity can occur. For example, for advanced non-small cell lung cancer, if the patient is in good health and receives chemotherapy, it will only prolong the median survival time by 1 to 3 months. If the patient is in poor health and receives chemotherapy, he/she will not even get any benefit. 3. Why do oncologists in western hospitals tend to advise patients to undergo repeated chemotherapy? There are several reasons: Firstly, for advanced tumors, there are really no more choices of methods, they don’t understand Chinese medicine, only chemotherapy, chemotherapy, and then chemotherapy. Secondly, Western hospital tumor patients have relatively good physique during the initial treatment, even if the chemotherapy is ineffective, they can withstand repeated chemotherapy again and again until their body can no longer withstand it, and the hospital will not admit them anymore, and the patients will be advised to switch to Chinese medicine treatment. Third, the Western hospital patients for the first time, the economy is relatively good, can afford all kinds of imported drugs, self-financed drugs, expensive drugs, in fact, the efficacy of mediocre. 4, that is not the need for chemotherapy? Not, chemotherapy or not, need to first assess the risk and benefit. If the benefit outweighs the risk, then chemotherapy is supported. When is the benefit likely to outweigh the risk? If it is the first chemotherapy treatment, the prerequisites are: evidence-based medicine has proven that chemotherapy has a significant effect on the disease, and the patient’s body can tolerate the toxicity. If it is not the first chemotherapy treatment, the prerequisite for another chemotherapy treatment is that the first 2 to 3 chemotherapy treatments have shown significant results and the body can continue to tolerate the toxicity. If the patient is post-surgical and the tumor has been removed, is chemotherapy needed? This also requires an assessment of the risks and benefits. The prerequisites for this are: first to stage the disease (post-surgical examination), and then to find out whether evidence-based medicine confirms that chemotherapy is significantly effective for that stage of the disease and that the patient’s body is able to tolerate the toxicity. It is difficult to derive benefit from chemotherapy or radiotherapy after early stage cancer has been surgically removed. 5. Any treatment, at all times, should adhere to a person-centered approach rather than a disease-centered approach. Chemotherapy should not be given for the sake of completing chemotherapy, but must take into account the patient’s body. In the case of chemotherapy is not yet the overall efficacy of the situation, it is best to stop, point to point, otherwise the end of chemotherapy, the person also went to the West. Luo Jing, the famous anchor of CCTV, suffered from lymphoma, and from the reports, he had gone through 9 times of intensive chemotherapy, and as a result, in less than 10 months, his bone marrow and hematopoietic function were exhausted, and he died at a young age. Did he die of cancer itself? It is important to know that, for lymphoma, at present, no matter Chinese medicine or Western medicine, the cure rate is very high, with a 5-year survival rate of 50%. Luo Jing was usually in good health and loved to exercise, even without any treatment, he should be able to live for 10 months. In the clinic, the death of excessive chemotherapy patients abound. 6, there is a category of chemotherapy to be more cautious, that is: only tumor markers such as CEA, CA125, etc. are elevated, and no tumor foci are found to grow or recur, and there are no symptoms of the case, in the end, do we need chemotherapy? There are 2 opinions at home and abroad: one is that elevated markers indicate active tumor and need chemotherapy. The other is that the tumor lesion is not growing and chemotherapy is not needed for the time being. My opinion is that chemotherapy is not needed for the time being for the following reasons: (1) Advance chemotherapy will lead to drug resistance of the tumor, and by the time the tumor really recurs, there will be no drug available. Therefore, early chemotherapy will overdraw future treatment means. (2) Advance chemotherapy will reduce the quality of life of patients in advance, lower the immunity of patients, and even if the tumor recurrence is delayed (not yet certain), it will not necessarily prolong life. (3) Cancer indicators such as CA125 will not affect the patient’s life and quality of life, so what is the urgency of treatment? What affects life is the tumor foci. If chemotherapy is given without seeing the tumor foci, there is suspicion of over-treatment, not to mention that chemotherapy is not effective for most of the tumors. (4) Even after the tumor grows and recurs, we can adopt more appropriate and effective methods such as surgery, radiotherapy and intervention according to the actual situation, and it is not necessary to use chemotherapy with poor efficacy and high toxicity. (5) In addition to chemotherapy, for those with elevated cancer indicators, we can also use Chinese medicine with low toxicity to treat them, which can also reduce the cancer indicators in many cases. In the clinic, there are many cases in which CA125 has risen to several hundred and more than one thousand, but after Chinese medicine treatment, it has dropped a lot. Even if Chinese medicine treatment is temporarily ineffective, it is at least harmless.