Dinoprostenone suppository 24 hours without effect may exist in the quality of drugs, the user themselves, dosage and other aspects of the reasons, need to be specifically analyzed. 1. Drug quality: when the use of dinoprostenol suppositories have quality problems or have expired, will affect its pharmacological effect, that may lead to the use of the situation of ineffective. 2. The user himself: if the user of the drug is less sensitive to the dinoprostenol suppository, or does not meet the indications for the drug (i.e., cervical Bishop score of ≤ 6 after 38 weeks of gestation, single fetus with head first exposure with the need to induce labor to promote the beginning of cervical ripening and/or continue to ripening), may lead to ineffective use of the drug. 3. Dosage: Dinoprostenone suppository is used as 1 pessary/times (specification 10mg/pessary), the suppository is taken out from the freezer and placed directly into the vagina, so that it is placed horizontally in the fornix, and bed rest is required for 20~30 minutes after placing it in the vagina, and if full cervical ripening has not been achieved within 8~12 hours, the suppository should be taken out and replaced with the second one, and the second one should be taken out in no more than 12 hours. If the medication is not standardized, it may be ineffective. It should also be noted that the use of dinoprostenol suppositories is contraindicated in people who are allergic to it, or in the presence of labor that has begun, oxytocin is being given, pelvic inflammatory disease, multiple pregnancies, etc. There is also the possibility of an abnormal fetal heart rate, uterine turgor and other adverse reactions during the use of the drug. To sum up, there are many possible reasons for the lack of effect of 24 hours of using Dinoprostenol suppositories, which should be analyzed under the guidance of the doctor in conjunction with the actual situation of the individual, and then dealt with accordingly after clarifying the reasons. Do not make blind judgment and dispose of it on your own to avoid adverse consequences.