When combining dapagliflozin and metformin, the minimum dosage is usually started as: dapagliflozin 5mg once daily; metformin 500mg twice daily. Depending on glycemic control, this may be increased to: dapagliflozin 10mg once daily; metformin 1000mg twice daily. Dagliflozin is a sodium-glucose co-transporter protein 2 inhibitor, which controls renal glucose reabsorption and thus lowers blood glucose. It is used for glycemic control in adults with type 2 diabetes. The recommended starting dose is 5mg per dose, which may be increased to 10mg once daily in patients requiring increased glycemic control. Adverse reactions include genital fungal infections, urinary tract infections, and increased urination. Metformin belongs to the class of drugs called biguanides, which exert hypoglycemic effects by increasing insulin sensitivity and so on. Adults start to take 500mg orally each time, 2~3 times/day, and try not to exceed 2g a day.Adverse reactions include lack of appetite, bloating, nausea and diarrhea. It is not suitable for patients with diabetic coma and ketoacidosis, severe infections. When Dagliflozin and Metformin are used in combination, it is usually taken from the smallest dosage, and the blood glucose is regularly rechecked. If the blood glucose control is unsatisfactory, the dosage of the drug can be gradually increased, and it is necessary to take the drug under the guidance of a professional doctor, so as not to lead to the unsatisfactory control of blood glucose, which may lead to the occurrence of diabetic complications.