Anti-SSA antibodies are a type of antinuclear antibody, and it is possible for a positive test to turn negative. Anti-SSA antibodies are the most common test used in autoimmune disease screening and are an indicator of whether autoantibodies are normal. In normal people, the results of this test are negative, while a positive antibody test indicates the presence of certain diseases. Clinical diseases that can cause positive anti-SSA antibody test results include primary dry syndrome, systemic lupus erythematosus, primary biliary cirrhosis, hepatitis, and neonatal lupus syndrome. It is possible that the antibody can turn negative after active and effective treatment. It is recommended that patients with positive anti-SSA antibodies should go to the hospital in time and follow the doctor’s instructions for active treatment to avoid delaying their condition.