Anterior chest and back pain should first be excluded from cardiogenic chest pain, that is, chest pain caused by angina pectoris, myocardial infarction and other causes. This kind of disease needs to consult the cardiology department and perform relevant tests to exclude it. After excluding cardiogenic chest pain, 80% of non-cardiogenic chest pain is of esophageal origin. Among esophageal diseases, the most common one is gastroesophageal reflux disease, which is caused by the reflux of stomach and duodenal contents into the esophagus, causing damage to the esophageal membrane and resulting in chest pain. Reflux and heartburn are the most common clinical manifestations, and chest pain can also be seen in patients with GERD. In this group of patients, it is recommended to consult a gastroenterologist for a complete gastroscopy, except for reflux esophagitis and Barrett’s esophagus. In terms of treatment, oral medication to suppress stomach acid and promote gastric motility is required.