Every day to take antihypertensive drugs on the kidney has a certain effect, the excretion of drugs is mainly through the kidneys and liver, but each antihypertensive drugs have corresponding side effects, as long as it is not a large dose of diuretic antihypertensive drugs, basically will not hurt the kidneys. Antihypertensive drugs include diuretic antihypertensive drugs, adrenergic receptor blocking drugs, angiotensin-converting enzyme inhibitors, calcium antagonists and so on. The most common side effects of diuretic antihypertensive drugs, such as hydrochlorothiazide and furosemide, are electrolyte disorders and elevated uric acid. Beta-blockers, such as propranolol, etc., it will reduce cardiac output, reduce renal blood flow, use should pay attention to monitor renal function. Angiotensin receptor inhibitors, such as valsartan, irbesartan, etc., angiotensin-converting enzyme inhibitors, such as captopril, etc., can dilate the glomerular arteries, reduce the amount of urinary protein, long-term use of renal function can be protected, but note that short-term application can be transiently slightly increased blood creatinine levels. Calcium ion antagonist drugs, such as nifedipine, verapamil, side effects include headache, edema, flushing, etc.. Correctly look at the side effects of drugs, do not delay the condition because of side effects dare not take drugs. Smaller impact on renal function, hypertension combined with heart failure when applying this type of drug may cause heart failure aggravation, may cause renal perfusion insufficiency. If uncomfortable symptoms appear, it is recommended to consult a doctor in time and standardize the treatment under the guidance of the doctor.