Acne is medically known as acne, and the appearance of acne during menstruation can usually be treated with topical and oral medications. Before a woman’s menstrual period, estrogen and progesterone levels drop, while androgen levels are relatively high, which will stimulate the sebaceous glands to secrete a large amount of oil. The oil will easily accumulate under the skin with the shed skin tissues, resulting in the formation of acne, which is manifested by the appearance of pimples, pustules, and comedones on the surface of the skin. 1. Topical medication: Topical Vitamin A cream, benzoyl peroxide and other medications can be used topically, as well as erythromycin cream, clindamycin cream and other topical medications, suitable for patients with mild symptoms. 2. Oral medication: For patients with severe symptoms, in addition to externally applied medication, oral medication such as isotretinoin can be applied, and antibiotics such as roxithromycin capsule and doxycycline hydrochloride capsule can also be taken orally. All of the above drugs should be used under the guidance of a professional doctor to avoid self-medication. It is recommended to go to the hospital in time for treatment of acne during menstruation. Daily attention should be paid to avoid scratching and squeezing the affected area, which is easy to damage the skin and secondary bacterial infection, thus aggravating the symptoms.