Red, swollen and hard pimples on the cheeks are mainly caused by folliculitis and acne, and need to be treated with medication and oral medication under the guidance of a doctor. 1. Folliculitis: Folliculitis is a purulent inflammation confined to the mouth of the hair follicle caused by bacterial infection, with lesions appearing as red follicular papules and red, swollen and hard pimples. Attention should be paid to skin cleanliness and hygiene, prevention of trauma and enhancement of the body’s immunity. Topical medication is the mainstay of treatment, and can be applied to fusidic acid cream, mupirocin ointment and other medications. 2. Acne: Acne is mainly due to the exuberant secretion of sebaceous glands, keratinization of sebaceous gland ducts, and the propagation of Propionibacterium acnes, etc. The lesions will lead to blockage and narrowing of hair follicle openings, which will prevent sebum from being discharged, and will be manifested as red, swollen, and hard pimples on the cheeks. It can be treated by applying retinoids, benzoyl peroxide ointment, or taking oral retinoids and other medications. Red, swollen and hard pimples on the cheeks may also be caused by insect bites, sebaceous cysts, etc., which need to be treated by a doctor. All of the above medications should be used under a doctor’s supervision.