Laparoscopy as a treatment for high-grade colorectal cancer patients

  Worldwide, population aging has become a serious issue for countries to focus on. According to the World Health Organization, it is predicted that by 2050, 2 billion people worldwide will be over 60 years old, accounting for 23% of the total population. Along with the aging population, the proportion of elderly colorectal cancer patients is also increasing, with more than 70% of colorectal cancer patients in Western countries being older than 65 years old in 2000. With the implementation of the basic national policy of family planning, China has also accelerated the process of population aging, and the proportion of elderly colorectal cancer patients has gradually increased. Therefore, while aging is increasing, how to treat senior colorectal cancer patients is a serious problem facing the clinic.  Since Jacobs first introduced laparoscopic technology into the treatment of colorectal cancer, several large-scale randomized controlled clinical studies on laparoscopic treatment of colorectal cancer have been conducted internationally. After more than a decade, these clinical trials have reported their immediate and long-term efficacy. The results show that laparoscopic treatment of colorectal cancer not only has the same proximal and distal tumor margins and the same extent and number of lymph node dissection as traditional open surgery, but also has more advantages in terms of surgical bleeding, recovery of bowel function, length of hospital stay, and use of pain medications. In addition, laparoscopic treatment of colorectal cancer not only has the same 5-year survival rate as open surgery, but also has better efficacy in some colon cancer patients, so laparoscopic surgery has become the trend of colorectal cancer treatment.  ”The definition of “advanced age” has not been standardized in previous clinical studies, and the WHO currently defines people between 60 and 75 years old as young elderly, while people above 75 years old are defined as advanced elderly. Therefore, the concept of “advanced age” refers to people above 75 years old.  With the increase of age, the regenerative capacity of tissues and cells of the body decreases, resulting in slow recovery of body functions after surgery, delayed healing of anastomosis and incision, and complications such as anastomotic fistula, incision dehiscence, and incision infection. Thus, for elderly patients, the complication rate and mortality rate of traditional open surgery are on the rise with increasing age.  At present, with the advancement of laparoscopic surgery research and the maturation of technology, laparoscopic surgery time has been greatly reduced and is not longer than open surgery. Moreover, compared with traditional open surgery, the exposure time to internal organs is shorter and less disturbed, and the physiological function is less disturbed, while the abdominal wall incision is small and the trauma reaction and inflammation reaction are mild. Therefore, theoretically, laparoscopic surgery in elderly patients should be safer than open surgery.  Increased cardiopulmonary complications after surgery are a distinctive feature of elderly patients compared to younger patients. In the last decade or so, domestic and international studies have found that laparoscopic surgery not only does not increase the incidence of cardiopulmonary complications such as pneumonia and coronary artery disease, but also decreases the incidence of such complications compared with open surgery. In addition, these studies have shown that laparoscopic surgery is associated with less bleeding, faster recovery of bowel function, lower rates of incisional infections, and shorter postoperative hospital stays, and no differences in anastomotic fistula and perioperative mortality between the two groups. Therefore, laparoscopic surgery is recommended in patients of advanced age.  Therefore, advanced age should not be a contraindication to laparoscopic surgery, and with active evaluation and treatment of preoperative comorbidities and enhanced perioperative monitoring, laparoscopic surgery does not increase the incidence of postoperative complications in elderly patients, while the recent efficacy is significantly better than that of open surgery, safe and reliable, and should be the preferred surgical treatment for elderly colorectal cancer patients.