Blisters, medically, are referred to as blisters. Skin blisters are considered to be related to physical factors such as burns, inflammatory skin diseases such as eczema, infectious skin diseases such as herpes, and autoimmune diseases such as pemphigus. 1. Physical factors: such as burns. If the patient’s local contact with hot water or water vapor, due to local tissue destruction, resulting in cells, tissue fluid from the cell space exudation and the appearance of small blisters, serious cases will lead to local tissue yellow or black, combined with local sensory abnormalities. 2. Inflammatory skin diseases: such as eczema. Due to internal and external stimulation by a variety of factors and the occurrence of an inflammatory disease. Clinically, it mainly manifests as erythema, papules, papules, blisters, vesicles, oozing, etc., accompanied by itching. 3. Infectious skin diseases: such as herpes. Mainly caused by herpes simplex virus, varicella zoster virus infection, the main clinical manifestations of erythema clustered small blisters, or banded arrangement, accompanied by pain. 4. autoimmune diseases: such as pemphigus. Due to autoimmune disorders and a chronic herpetic dermatosis, clinically mainly manifested as loose blisters on the skin and mucous membranes, accompanied by erosion. For patients with blisters on the skin, it is recommended that they go to a regular hospital, clear cause of the disease under the guidance of the doctor active treatment.