Postherpetic neuralgia (PHN) is a neuropathic pain, which originates from residual nerve damage after herpes zoster virus attack, and manifests as severe radiating pain and abnormal sensation along the innervation zone, and the pain can last for decades. For patients with mild postherpetic neuralgia, conservative treatment such as medication and peripheral nerve block can be used, and pain can be well controlled in more than 60% of patients after conservative treatment. For a small number of patients with PHN whose pain is still not controlled by regular conservative treatment, minimally invasive interventional treatment of ganglion, spinal cord electrical stimulation, and in vivo morphine pump can be used. Severe postherpetic neuralgia can be very painful and seriously affect the quality of life, and the longer it takes, the more difficult it is to treat. The likelihood of developing postherpetic neuralgia is higher in patients with severe pain at the beginning of herpes. In addition, elderly patients and immunocompromised patients (e.g., patients with concomitant malignancy) are more likely to develop postherpetic neuralgia after herpes zoster.