The severity of T-wave hypoplasia is judged by its state and the degree of hypoplasia. In patients with organic heart disease, T-wave hypoplasia occurs during exercise, emotional stress, and other conditions, and the depression is obvious, accompanied by obvious symptoms, which is very serious, considering coronary artery disease, acute myocardial ischemia, and acute coronary syndrome, requiring drug treatment. If necessary, coronary intervention or surgical coronary artery bypass grafting is given. In the physiological state, T-wave hypoplasia can be caused by strenuous exercise and can be relieved by avoiding the relevant triggers. If necessary, myocardial nourishing drugs such as trimetazidine and coenzyme Q10 are given for symptomatic management. In addition, for other diseases, such as cardiomyopathy and myocarditis, T-wave hypoplasia can also occur and requires targeted treatment, the severity of which is related to the primary cause.