Headache and nausea are common clinical symptoms, headache and nausea at the same time are mainly seen in migraine, cerebral hemorrhage, cerebral infarction, glaucoma. There are the following reasons: 1, migraine headache is mostly seen in female patients, the etiology is unknown, often triggered by fatigue, mental excitement, mainly manifested as orbital and temporoparietal vascular throbbing headache, mostly occurring on one side. 2, cerebral hemorrhage, cerebral infarction is mostly seen in the elderly, the patient has a history of hypertension, diabetes mellitus, hyperlipidaemia, etc., the emergence of the symptom of headache and nausea is more acute, often accompanied by limb weakness, sensory deficits, difficulty in swallowing, etc., in serious condition, the symptoms of headache and nausea are more urgent. The headache and nausea symptoms appear more rapidly, often accompanied by limb weakness, sensory impairment, distorted mouth and eyes, dysphagia, etc., the condition is serious can appear consciousness disorder, incontinence, cranial CT or cranial magnetic resonance examination, can be further clarified the diagnosis. 3, glaucoma belongs to the ophthalmology disease, due to the atrial fluid circulation obstacles caused by intraocular hypertension, the patient, in addition to the headache and nausea, but also have blurred vision, photophobia, orbital distension and pain, the emergence of headache should be timely to go to the hospital, as soon as possible to clarify the cause of the symptomatic treatment. The cause of headache should be clarified as soon as possible and treated symptomatically, it is not recommended to take painkillers orally.