Low platelets should not be taken with antipyretic and analgesic drugs such as ibuprofen, aspirin, diclofenac sodium and other cold medicines, which may induce bleeding. Platelets have the role of promoting hemostasis and preventing bleeding, and when the platelet count is low, the risk of bleeding increases. Antipyretic and analgesic drugs are commonly used cold and flu medications today, and some of these drugs can inhibit platelet aggregation and reduce platelet count, increasing the risk of bleeding. Cold medicines, including aspirin, diclofenac sodium and ibuprofen, are non-steroidal anti-inflammatory drugs, which can inhibit the synthesis of prostaglandins, making local pain receptors less sensitive to pain-causing substances such as bradykinin, exerting an analgesic effect and exerting an antipyretic effect. It can inhibit the enzyme cyclooxygenase, thus having a strong and irreversible inhibitory effect on platelet aggregation. Cold medicines may cause allergies, gastrointestinal reactions, liver and kidney function injury and other adverse reactions, drug allergies or severe liver and kidney function injury patients are prohibited such drugs, the use of drugs need to be under the guidance of a professional doctor, low platelets combined with colds, it is recommended that timely medical treatment, standardized treatment.