Levofloxacin and norfloxacin have different chemical structures and have different clinical applications. Levofloxacin is also known as levofloxacin. Both levofloxacin and ofloxacin belong to quinolone antibiotics. 1. Structural differences: Levofloxacin is the levofloxacin, which is researched on the basis of norfloxacin. Norfloxacin belongs to the second generation of antibiotics, and levofloxacin belongs to the third generation of antibiotics. Compared with norfloxacin, levofloxacin has better antibacterial effect and fewer side effects. 2. The scope of clinical application is different: the use of norfloxacin has limitations, the effect on the intestinal flora is better, generally used for the treatment of a series of infections caused by sensitive bacteria, such as urinary tract infections, intestinal infections, prostatitis and so on. Levofloxacin has a good antibacterial effect and can be used to treat urinary tract infections, reproductive system infections, respiratory tract infections, lung infections, etc. caused by sensitive bacteria. Norfloxacin has been reported to have serious adverse reactions, antibiotic drugs should be used in strict accordance with the requirements of the doctor, reasonable use of medication, the abuse of antibiotics may allow the body to develop drug resistance, should be used in accordance with medical advice.