The treatment of one eye big and one eye small should be analyzed according to the specific situation. If it is congenital, generally no special treatment is needed, but if it affects the aesthetics, surgical treatment is feasible. If it is caused by acquired lesions, the patient can be operated according to the situation. One eye and one eye is small partly due to congenital factors, there is no other clinical manifestations and discomfort, you can first observe, do not do special treatment. If one eye has a single eyelid and the other has a double eyelid, the patient can undergo surgery under the guidance of a doctor to improve the appearance of the eye. If one eye looks different due to ptosis, the patient should go to the hospital first, and under the guidance and advice of the doctor, under the exclusion of other pathologies, ptosis correction surgery can be performed to improve the situation. If one eye is big and the other is small due to orbital tumor, intraocular space occupation, or deformity formed by trauma, patients need to go to the hospital for a detailed examination, and then undergo surgical treatment according to the results of the examination, such as surgical resection of the mass. It is recommended that patients with different sizes of eyes should consult a doctor in time to evaluate their condition and follow the doctor’s instructions for treatment.